Epigenetics相关论文
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Affection of Single-Nucleotide Polymorphisms in miR-27a, miR-124a, and miR-146a on Susceptibility to
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血-睾屏障由相邻支持细胞间多种蛋白质复合体组成，它通过在生精上皮参与构建生精微环境、提供免疫屏障并赋予细胞极性来维持正常精......
脓毒症为机体对感染的反应失调而导致危及生命的器官功能障碍，其发病机制复杂，病死率高。深入开展基础研究是突破脓毒症临床诊疗"瓶......
目的探讨组蛋白去乙酰化酶11(HDAC11)抗乙肝病毒(HBV)的体内效果和毒性。方法选取4~6周龄雄性C57BL/6 (H-2b)小鼠，通过尾静脉高压水......
Diabetes has become the epidemic of the 21 st century, and with over 90% patients with diabetes becoming at a risk of de......
目的DNA甲基化成为近年来表观遗传学的研究热点。越来越多的研究表明DNA甲基化在情感障碍的发病中也扮演着重要角色。本文综述了DN......
目的探讨注意缺陷多动障碍(attention deficit hyperactivity disorder ，ADHD)患儿和正常儿童在多巴胺转运体基因(DAT1/SLC6A3)、多......
目的探讨双相障碍Ⅰ型患者在躁狂发作时的血清5-羟色胺1A受体(5-hydroxytryptamine receptor 1A，HTR1A)基因启动子区甲基化水平。方......
微小RNA(miRNA)是一类能在转录后水平对靶mRNA进行调控的非编码小RNA,在多种生物学过程中发挥重要的调节作用,属于表观遗传学范畴.......
地方性砷中毒是我国政府高度重视的地方病，但受砷致病机制不明、缺乏癌变早期诊断指标以及无特效治疗药物等限制，地方性砷中毒尚未得......
目的观察饮水砷暴露对人群外周血白细胞中组蛋白H3第4位赖氨酸三甲基化（H3K4me3）和H3第79位赖氨酸三甲基化（H3K79me3）修饰水平的影响，分......
本综述介绍了NTDs(神经管缺陷)的疾病特点，总结了目前国际及国内范围对该病的病因研究情况，综合近五年的对该病的表观遗传发病机制研......
表观遗传学的主要内容是研究在不改变DNA序列的前提下调控遗传物质表达的过程及其机制。表观遗传调控过程十分复杂，主要包括DNA甲基......
你父母的悲惨童年或出色的冒险经历，都可能通过改变大脑里基因的表观遗传学信息而遗传给你，从而改变你的个性，赋予你或焦虑或达观的性......
近年来,越来越多的研究表明表观遗传学(epigenetics)与多种疾病密切相关。而胚胎发育的不健全是导致自然流产的重要原因。本文中,......
Type 1 diabetes (T1D) is an autoimmune disease that resulted from the severe destruction of the insulin-producing β cel......
Effects of a multimodal exercise protocol on functional outcomes, epigenetic modulation and brain-de
Epigenetic changes have been shown to be associated with both aging process and aging-related diseases. There is evidenc......
Multifaceted role of one-carbon metabolism on immunometabolic control and growth during pregnancy, l
Dairy cattle undergo dramatic metabolic, endocrine, physiologic and immune changes during the peripartal period largely ......
Ischemic stroke occurs under a variety of clinical conditions and has different pathogeneses, resulting in necrosis of b......
Integrating transcriptomes and somatic mutations to identify RNA methylation regulators as a prognos
Background: RNA methylation modifying plays an important role in the occurrence and progression of a range of human canc......
Sporadic late-onset Alzheimer’s disease (SLOAD) and familial early-onset Alzheimer’s disease (FEOAD) associated with d......
Multiple sclerosis is a chronic,inflammatory and degenerative disease of the central nervous system of unknown aetiology......
Parkinson’s disease(PD)is one of the most debilitating brain diseases.Despite the availability of symptomatic treatment......
Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,respectively.The interest in underst......
甲基苯丙胺(methamphetamine,MA)属于苯丙胺类中枢兴奋剂(amphetamine-type stimulants,ATS)。MA和阿片类传统毒品相比,最大的区别......
N6-methyladenosine (m6A) is the most common post-transcriptional RNA modification throughout the transcriptome,affecting......
,Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-s
Bromodomain PHD-finger transcription factor (BPTF) is the largest subunit of the nucleosome remodeling factor and plays ......
Bisulfite sequencing (BS-seq) technology measures DNA methylation at single nucleotide resolution.A key task in BS-seq d......
OBJECTIVES:Single nucleotide polymorphisms (SNPs),genetic background,and epigenetics play important roles in rheumatoid ......
Dynamic changes of the post-translational O-GlcNAc modification (O-GlcNAcylation) are controlled by O-linked β-N-acetyl......
Myocardial infarction afflicts close to three quarters of a million Americans annually,resulting in reduced heart functi......
Epigenetic modifications,including those on DNA and histones,have been shown to regulate cellular metabolism by controll......
Leaf senescence is driven by the expression of senescence-associated genes (SAGs).Development-specific genes often under......
Seed development in angiosperms requires a 2∶1 matal-to-patal genome ratio (2m∶1p) in the endosperm.When the ratio is ......
Advances in the detection and mapping of messenger RNA (mRNA) N6-methyladenosine (m6A) and 5-methylcytosine (m5C),and DN......
Th1、Th2细胞分化及其相互之间的平衡在免疫应答的调节中起重要作用,Th1/Th2细胞分化受多种因素影响,其中,转录因子T-bet、GATA-3......
组蛋白修饰是表观遗传修饰的重要方式，在基因表达的调控中扮演重要角色。常见的组蛋白修饰包括组蛋白乙酰化和甲基化。自身免疫性疾......
Type 2 diabetes mellitus and metabolic disorders have become an epidemic globally. However, the pathogenesis remains lar......
Non-coding RNAs (ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs (tRNAs), a type of ncRNA,......
近年研究发现,环境致癌物苯并(a)芘的致癌机制除遗传毒性外,可引起全基因组甲基化减低、抑癌基因甲基化升高及原癌基因甲基化降低,......
该文从挂篮荷载计算、施工流程、支座及临时固结施工、挂篮安装及试验、合拢段施工、模板制作安装、钢筋安装、混凝土的浇筑及养生......
