Chronic inflammation promotes tumor development,progression,and metastatic dissemination and causes treatment resistance......

The changes associated with malignancy are not only in cancer cells but also in environment in which cancer cells live.M......

砷是一种广泛存在于自然环境中的具有致癌作用的非金属物质。慢性砷暴露会造成全身多器官损伤，因其发病机制不明确、缺乏特效药及早......

With the rising incidence of cardiovascular diseases,the concomitant mortality and morbidity impose huge burdens on qual......

The causal mechanisms and treatment for the negative symptoms and cognitive dysfunction in schizophrenia are the main is......

Lysine acetylation,one of the major types of post-translational modifications,plays critical roles in regulating gene ex......

Obesity has reached epidemic proportions globally.Although modern adoption of a sedentary lifestyle coupled with energy-......

How distinct transcriptional programs are enacted to generate cellular heterogeneity and plasticity,and enable complex f......

Ovary plays an important role in the female reproductive system.The maintenance and regulation of ovarian function are a......

Chinese medicine (CM) has contributed to human health care for several thousand years and is still popular in Asian coun......

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Via quantitative polymerase chain reaction (qPCR) test method,the efficacy of hexapeptide-2 was studied,including silenc......

Extensive incorporation of engineered nanomaterials(ENMs)into industrial and biomedical applications increases the risks......

Vitrification has been widely employed to cryopreserve animal and human oocytes and embryos.It can not only promote oocy......

Introduction: Osteoarthritis (OA) is the most common degenerative disease of the synovial joint. Suppressing IL-6 overex......

Purpose Adolescent idiopathic scoliosis(AIS),the most common pediatric spinal deformity,is considered a complex genetic ......

Osteoporosisisoneofthemostprevalentskeletalsystemdiseases;yet,itspathophysiologicalmechanisms remainelusive.Adipocytesac......

Drug addiction is a psychiatric disorder characterized by an increasing consumption of drugs with enhanced motivation at......

Protein arginine methyltransferase 1(PRMT1)is an important member of PRMT subfamily,which catalyzes the transfer of a me......

The phenomenon by which monocytes and other immune cells render tolerant after repetitive exposure to LPS is known as en......

Trimethylation of histone H3K36 is a chromatin mark associated with active gene expression, which has been implicated in......

Background: To recognize a novel and optimized combination of epigenetic biomarkers capable of returning higher sensitiv......

Both kinetic metabolic fluxes and expression of metabolic genes display robust circadian rhythms across all major metabo......

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As the first identified histone demethylase,Lysine specific demethylase 1(LSD1)plays an important role in epigenetic reg......

Objective: To recognize a novel and optimized combination of epigenetic biomarkers capable of returning higher sensitivi......

The post-translational modifications of histone, eg methylation and demythalation,regulate chromatin structure as well a......

Background & Aims: The hepatitis B virus X protein (HBx) has been implicated as an oncogene in both epigenetic modificat......

Liver cancer is the fifth most common cancer in the world and the third most common cause of cancer-related death.Overal......

Objective: Human mesenchymal stem cells(MSCs)are multipotent progenitor cells with self-renewal capabilities and multili......

Objective Some studies have shown that Lysine Methyltransferase 2C(KMT2C),a relative gene of histone methyltransferase f......

Cancer pain is a major clinical challenge and one of the most common symptoms of patients with malignant tumor,and the m......

Gout arthritis is the most common inflammatory and immune disease, and the prevalence and incidence of gout increased fo......

The involvement of the hepatitis B virus X (HBx) protein in epigenetic modifications during hepatocarcinogenesis has bee......

Recently,long non-coding RNA is thought to be contained in human genome as important regulatory transcripts in which we ......

Objective Epigenetic modifications such as DNA methylation are known to participate in the development of depression in ......

Transcription factors(TFs)and chromatin-modifying factors(CMFs)access chromatin by recognizing specific DNA motifs in th......

A key step towards generating fertilization-competent eggs is the maturation of oocytes.Oocyte maturation encompasses in......

The post-translational modifications of histone,e.g.methylation and demythalation,regulate chromatin structure as well a......

Malignant tumors are exemplified by excessive proliferation and aggressive migration/invasion contributing to increased ......

Polyploidization,or whole genome duplication(WGD),is the pervasive driving force for different flowering plants.Polyploi......

Background: DNA methylation plays a crucial role in the occurrence of complex diseases.Genes that interact directly or i......

Coordinated changes in multiple gene networks are emerging to be a key determinant of axon regeneration.Epigenetic regul......

Objective Tenovin-6 is a newly reported small molecular inhibitor of Class Ⅲ HDACs or Sir2 family of enzymes.It has bee......

Objectives:To detect the global gene expressions of human embryoid bodies after disposing by bisphenol A.Methods:Human E......

In addition to DNA cytosine methylation(5-methyl-2-deoxycytidine,m5dC),DNA adenine methylation(N6-methyl-2-deoxyadenosin......

Aberrant epigenetic alterations of tumor suppressor genes have been recognized as a driving force in cancer.Histone deac......